澳門科學館由著名建築師貝聿銘設計，以推動青少年科普教育、配合澳門旅遊發展及作爲地區性科普教育及會展平台為宗旨。2009年12月19日，中共中央總書記、國家主席胡錦濤及澳門特別行政區行政長官何厚鏵在此主持新館開幕典禮。
Macao Science Center was designed by Pei Partnership Architects in association with I. M. Pei, it aims to promote science popularization and education among local adolescents, compliment tourism development in Macao and provide a regional platform for science education, convention and exhibition. Mr. Hu Jintao, President of the People’s Republic of China and Mr. Ho Hau Wah, the Chief Executive of Macao SAR inaugurated the Opening Ceremony of the Center on 19 December 2009.
